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1. What other type of treatment do you want to administer concomitantly?
2. In which category is the drug you want to administer concomitantly?
Information about interaction with CYP3A1
|STRONG INHIBITOR||MODERATE INHIBITOR||WEAK INHIBITOR||STRONG INDUCTOR||MODERATE INDUCTOR||WEAK INDUCTOR|
|Effect on the sensitive index substrate (SS)||SS AUC increases 5 times||SS AUC increases from ≥2 to <5 times||SS AUC increases from ≥1.25 to <2 times||SS AUC decreases ≥80%||SS AUC decreases from ≥50% to <80%||SS AUC decreases from ≥20% to <50%|
|Clinical significance||Toxicity monitoring||Low risk of DDI||Low risk of DDI||Efficacy monitoring||Efficacy monitoring||Low risk of DDI|
|Recommendations||Consider lowering the substrate dose||Monitoring||None||Consider increasing the sustrate dose||Monitoring||None|